Use VoiceOver to select and deselect items on Mac

Select or deselect a single item or multiple items.

Note: VO represents the VoiceOver modifier. See Use the VoiceOver modifier.

Select an item: Press VO-Return.
Deselect an item: Press VO-Command-Return, or double-tap on the trackpad.
Select multiple items: Start interacting with a list or table, navigate to the first item, then press VO-Command-Return (this action temporarily turns cursor tracking off). For each additional item, navigate to it, then press VO-Command-Return. To stop selecting items, press the Escape key or Fn-Tab, or stop interacting with the list or table (this action turns cursor tracking on).
Deselect items: Navigate to an item, then press VO-Command-Fn-F4. VoiceOver deselects all items except the one in the VoiceOver cursor. To deselect that item, press VO-Command-Return.

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VoiceOver User Guide