Use VoiceOver to click a mouse on Mac
Use VoiceOver commands to simulate mouse clicks.
Note: VO represents the VoiceOver modifier.
Make sure the mouse pointer is on the item you want to click.
If you didn’t set the mouse pointer to follow the VoiceOver cursor (in the Navigation category of VoiceOver Utility), you must move the VoiceOver cursor to the item, then press VO-Command-F5 to place the pointer on the item.
To click the mouse, press VO-Shift-Space bar. To double-click the mouse, press VO-Shift-Space bar-Space bar.
You can use Mouse Keys to control the mouse pointer (except when the NumPad Commander is enabled).