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- Try moving external USB 3.0 devices further away from the computer, and away from your external Bluetooth devices. For example, if you think an external USB 3.0 hard drive may be causing an issue, try relocating the device away from your Mac or move it to another side of your Mac.

 
 - Make sure all USB cables are connected correctly. Better shielded USB 3.0 cables may also be helpful. 

Learn more
Here are some other articles that may be helpful:
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- Troubleshooting wireless mouse and keyboard issues 

- AirPort and Bluetooth: Potential sources of interference 

- Using USB 3 devices on Mac computers FAQ