OS X: Application icon has a prohibitory sign, or "PowerPC applications are no longer supported" appears

When attempting to open a PowerPC-based application, this alert appears: "You can't open the application (name of application) because PowerPC applications are no longer supported". PowerPC-based applications display a white prohibitory sign over their icon in the Finder.

Contact the manufacturer for an updated version of the software that is compatible with current versions of OS X.

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Some applications, such as Microsoft Office 2004 and DivX, may not be compatible with current versions of OS X.

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